It was four years since the first symposium on Personalized Cancer Care: Risk Prediction, Early Diagnosis, Progression and Therapy was organized in Oslo. Most of the speakers from 2012, the world leaders in their field, gave and update and their view on what we have achieved in these past four years throughout six inspiring sessions. The symposium was also a tribute to Anne-Lise Børresen-Dale and her important contribution to breast cancer research. Several members of the network were presenting their research orally and as poster presentations. The symposium was organized by Oslo University Hospital, Radium Hospital Foundation and Fritz Bender Stiftung.